AMP Molecular in a Minute: Microlearning Modules in Molecular Pathology

Person learning at computer

If you have a few minutes, these bite-sized 5-20 minute presentations are designed for a quick review, updates, and educational overviews by experts on a range of topics in molecular pathology. You can view these on your computer, tablet, or smart-phone to learn something new or to review material for an upcoming seminar, exam, meeting, or journal club.

Please scroll down for a selection of short presentations in different topic areas:

The Molecular Pathology Competency Series

These micro-learning modules are targeted to practicing laboratory professionals and cover many aspects of competency in the laboratory. They are short (10-15 minute) presentations covering Core (basic proficiency) or Advanced (specialized and/or recently updated) concepts in a particular area of laboratory training. This content addresses specific advances in training, technology, and laboratory operations and acts as review and/or updates in important principles for laboratorians over the full arc of their careers.

Title/Link	Speaker	Length
CORE: Biomarkers for Immunotherapy This core concept module provides information on the role of microsatellite status, tumor mutational burden levels and PD-L1 expression as biomarkers for immunotherapy of cancer.	Honey V. Reddi, PhD, FACMG	14 min
ADVANCED: Biomarkers for Immunotherapy This advanced concept module provides information on the role of microsatellite status, tumor mutational burden levels and PD-L1 expression as biomarkers for immunotherapy of cancer.	Honey V. Reddi, PhD, FACMG	12 min
CORE: Germline / Somatic Variants This core concept module covers the question: What are germline variants and somatic variants?	Alanna Church, MD	5 min
ADVANCED: Germline / Somatic Variants This advanced concept module answers the question: How do we approach the discussion of potential germline variants in tumor-only sequencing?	Alanna Church, MD	7 min
CORE: Lymphoid Clonality Testing This core concept module reviews the biological basis and clinical utility of lymphoid clonality testing.	Nathan Montgomery, MD PhD	18 min
ADVANCED: Lymphoid Clonality Testing This advanced concept module reviews PCR- and sequence-based methods of lymphoid clonality testing.	Nathan Montgomery, MD PhD	18 min

Utility of Cell-free DNA in the Clinic: Current State and Future Directions.

Molecular in a Minute modules on Liquid Biopsy core concepts and recent advances.

ctDNA Sequencing: A strategy for treatment response monitoring of aggressive B cell lymphoma
Description: This module will summarize the current knowledge related to circulating tumor DNA in patients with aggressive B cell lymphoma, such as diffuse large B-cell lymphoma and classical Hodgkin lymphoma, and discuss how ctDNA measurements can be used to monitor treatment response in the front-line setting.
Speaker: Rena Xian, MD
Length: 13 min
Recorded: May 18, 2021

How Accurate is That Test? Quality Assessment for Cell-Free DNA Tumor Tests
Description: This module summarizes laboratory error detection and reviews current quality monitoring for clinical laboratories performing cell-free tumor DNA tests.
Speaker: Christina Lockwood, MD
Length: 15 min
Recorded: July 21, 2021

Choosing the best circulating tumor DNA assay for your clinical application: technical and analytical considerations
Description: Dr. Moding discusses the fundamental differences between currently available circulating tumor DNA assays to help clinicians choose the best assay for their application.
Speaker: Everett Moding, MD
Length: 8 min
Recorded: September 23, 2021

Assessment of Laboratories offering cell free (cf)DNA screening for Down syndrome
Description: The CAP offers a bi-yearly external educational exercise for laboratories offering cfDNA based prenatal screening for common aneuploidies based on three clinical scenarios and results of testing prepared samples. A brief review of these results will include computation of maternal and gestational age as well as clinical results such as z-scores, clinical interpretation, assessing fetal sex and fetal fraction.
Speaker: Glenn E. Palomaki, PhD
Length: 13 min
Recorded: January 6, 2021

Error-Correction Strategies in NGS
Description: Dr. Patel discusses the error-correction strategies in NGS.
Speaker: Keyur Patel, MD
Length: 22 min
Recorded: March 24, 2022

Emerging and Evolving Biomarkers:

Each of these one-hour presentations has been divided into three 15-20 minute Molecular-in-a-Minute Modules: First, ~15 minutes on the most current scientific research (Scientific Underpinings), then ~15 minutes on laboratory considerations for marker testing approaches (Laboratory Considerations), and finally, ~15 minutes on the clinical implications of test results (Clinical Implications). Each module is linked in the table below, and a link to the full one-hour presentation is in the left-hand "Full Webinars" column. These modules were designed so that you can specifically target your learning/review needs.

MICROLEARNING MODULES
AUDIENCE

BIOMARKERS
FULL WEBINARS