Microlearning Modules

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These bite-sized presentations are designed for a quick review, updates, and educational overviews by experts on a range of topics in molecular pathology.  You can view these on your computer, tablet, or smart-phone to learn something new or to review material for an upcoming seminar, exam, meeting, or journal club.


Please scroll down for a selection of short presentations in different topic areas:

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The Molecular Pathology Competency Series

These microlearning modules are targeted to practicing laboratory professionals and cover many aspects of competency in the laboratory. They are short (10-15 minute) presentations covering Core (basic proficiency) or Advanced (specialized and/or recently updated) concepts in a particular area of laboratory training. This content addresses specific advances in training, technology, and laboratory operations and acts as review and/or updates in important principles for laboratorians over the full arc of their careers.


NEW Microlearning videos




CORE: Testing Modalities for Structural Variants

At the end of this core concept module, learners will be able to recognize and differentiate some of the techniques by which gene fusions are detected

Adam Fisch, MD, PhD

15 min

CORE: The role of RNA sequencing in interpreting splice variants

This core concept module will review how introns are spliced to create mature mRNA and describe how RNA sequencing is utilized in clinical laboratories to interpret potential splicing variants.

Heather McLaughlin, PhD, FACMG

22 min

CORE: Hybrid capture vs Amplicon based NGS

This core concept module learners will be able to describe both amplicon- and hybrid capture-based targeting sequencing enrichment methods.  The learners will be able to delineate the differences in technologies, as well as the advantages and disadvantages of each method, and in what clinical setting these techniques may be used.

Marjorie David, MS, MD

8 min

CORE: Identification of Mismatch Repair Deficiency by Next-Generation Sequencing

This core concept module learners will be able to define mismatch repair deficiency, understand the strengths and weaknesses of using next-generation sequencing to detect mismatch repair deficiency as compared to traditional methods, and describe the clinical relevance of mismatch repair pathway testing.

Jonathan Nowak, MD, PhD

10 min

CORE: Measurement of Tumor Mutational Burden

This core concept module  learners will be able to define tumor mutational burden, understand why tumor mutational burden can differ widely between tumors, and describe the relevance of tumor mutational burden to immunotherapy.

Jonathan Nowak, MD, PhD

5 min






CORE: Biomarkers for Immunotherapy

This core concept module provides information on the role of microsatellite status, tumor mutational burden levels and PD-L1 expression as biomarkers for immunotherapy of cancer. 

Honey V. Reddi, PhD, FACMG

14 min

ADVANCED: Biomarkers for Immunotherapy

This advanced concept module provides information on the role of microsatellite status, tumor mutational burden levels and PD-L1 expression as biomarkers for immunotherapy of cancer. 

Honey V. Reddi, PhD, FACMG

12 min

CORE: Germline / Somatic Variants

This core concept module covers the question: What are germline variants and somatic variants?

Alanna Church, MD

5 min

ADVANCED: Germline / Somatic Variants

This advanced concept module answers the question: How do we approach the discussion of potential germline variants in tumor-only sequencing?

Alanna Church, MD

7 min

CORE: Lymphoid Clonality Testing

This core concept module reviews the biological basis and clinical utility of lymphoid clonality testing.

Nathan Montgomery, MD PhD

18 min

ADVANCED: Lymphoid Clonality Testing

This advanced concept module reviews PCR- and sequence-based methods of lymphoid clonality testing.

Nathan Montgomery, MD PhD 18 min
CORE: Fluorescence in Situ Hybridization (FISH): Methodology and Clinical Utility

This core concept module reviews the methodology and clinical utility of fluorescence in situ hybridization (FISH) testing. 

Lori Ramkissoon, MD

13 min

CORE: Fusion Detection by Next Generation Sequencing Using RNA 

This core concept module will  review the structure of oncogenic gene fusions and the core principles of why and how we use RNA for fusion detection with NGS.

Alanna Church, MD

5 min

CORE: Quantitative PCR

This core concept module reviews how PCR can be used to quantify targets using delta Ct, standard curves, or digital PCR.  Here we discuss aspects of each approach.

Lawrence Jennings, MD

25 min

CORE: PCR and Sanger Sequencing

This core concept module will review PCR and Sanger Sequencing.

Va Lip

19 min

ADVANCED: Detection of a Cryptic Gene Fusion in a B-ALL 

This advance concept module will review the utility of targeted RNA sequencing to unravel cryptic gene fusions and how the sequencing results are reviewed, using a case-based approach.

Valentina Nardi, MD

15 min




AMP offers more Microlearning Modules:


Utility of Cell-free DNA in the Clinic: Current State and Future Directions.

Microlearning modules on Liquid Biopsy core concepts and recent advances. These microleanrning modules will cover new topics, advances, and applications for liquid biopsy in the laboratory and in the clinic


Emerging and Evolving Biomarkers Recent Findings, Laboratory Considerations, and Clinical Implications:

Microlearning modules are covered on the most current scientific research (Scientific Underpinings),  laboratory considerations for marker testing approaches (Laboratory Considerations), and on the clinical implications of test results (Clinical Implications). 





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