Syndrome MLH1, MSH2, MSH6, PMS2 (germline) LOF 40-60% lifetime risk of endometrial cancer SGA, NGS Eye Retinoblastoma RB1 LOF risk of hereditary cancer SGA, NGS GI Tract Hereditary Diffuse Gastric CA CDH1 (E-Cadherin) LOF risk of hereditary cancer SGA, NGS Gastrointestinal Stromal Tumor (GIST) SDHA, SDHB, SDHC, SDHD; KIT, PDGFRA LOF; Activating
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