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  1. 211.
    May 2014, AMP drafted and/or submitted comments in response to 14 dLCDs by MACs and of those, 26% of the requests resulted in changes in the final LCD. Based on the positive impact ... in the January issue of JMD, online at http://jmd.amjpathol.org/article/S1525-1578%2813%2900221-3/pdf. AMP reaffirmed its position that, for the vast majority of molecular tests
    https://www.amp.org/AMP/assets/File/committees/reports/2014_Committee_and_Subdiv...
  2. 212.
    GPM correctly identified all known large chromosomal variants (110 deletions/duplications and 27 rearrangements) with 100% concordance. It also uncovered 12 novel structural variants that were missed ... of this new method.” Key results of the study are as follow: 100% detection of known variants: GPM found all 110 previously identified copy-number variants
    https://www.amp.org/about/newsroom/amp-blog-content/new-3d-genome-mapping-tool-r...
  3. 213.
    An average of 192x106 total reads per sample were generated with 97% of >Q30 quality score. Between 2 and 50 reads spanning break points was detected per ... nuclei were scored by fluorescence microscopy. A case was confirmed positive for the rearrangement if ≥25% of the nuclei showed loss of the 5’-MGEA5 probe. Results: All 4 control cases demonstrated
    https://www.amp.org/AMP/assets/File/awards/technologist/Technologist_WinningAbst...
  4. 214.
    80% of the total volume of molecular services performed. Note: because these would be predominantly for high volume services, they would NOT represent anywhere near 80% of the total volume of DIFFERENT molecular services performed. 2) The large and growing number of ‘less common’ services for which assignment of an individual CPT code is limited by
    https://www.amp.org/AMP/assets/File/position-statements/2009/AMPCPTReformProposa...
  5. 215.
    Research shows that inherited genetic mutations play a major role in approximately 10% of cancers, including breast, ovarian, endometrial, prostate, pancreatic and colorectal.2 Major ... as bilateral salpingo-oophorectomy (removal of ovaries and fallopian tubes). Up to 25% of ovarian cancers are attributable to an inherited genetic mutation. The median age
    https://www.amp.org/AMP/assets/File/advocacy/RHCA_letter_03_13_2023Final.pdf?pas...
  6. 216.
    In this study, 91% of patients with methylated MGMT had pseudo-progression (versus 41% of patients without methylated MGMT, P = .0002), and were best managed by continuing the current therapy. The determination of MGMT promoter methylation status in post-treatment patients with imaging consistent with progression/psuedo-progression is thus clinically
    https://www.amp.org/AMP/assets/File/position-statements/2015/AMP-CAPResponse-MGM...
  7. 217.
    it exhibited excellent specificity (97%) and predictive value (88%) for identifying muscle-invasive bladder cancer,“ Medina said.. MYC produces a transcription factor crucial for regulating cell growth, proliferation and metabolism. Additionally, the researchers found that the ratio of large to small fragments of the housekeeping gene ACTB and the small
    https://www.amp.org/about/newsroom/amp-blog-content/a-simple-urine-test-for-blad...
  8. 218.
    For long term storage, RNA samples could be stored at -20ºC in 75% ethanol. Line 184 -Replace: …of “RNA samples” can be… With: …of “extracted RNA” can be… Line ... both to indicate "a non disease-causing change" or "a change found at a frequency of 1% or higher in the population". To prevent this confusion we do not use the terms mutation and
    https://www.amp.org/AMP/assets/File/position-statements/2008/AMPCommentsPGxDataS...
  9. 219.
    S1525‐1578%2815%2900071‐9/abstract ABOUT AMP: The Association for Molecular Pathology (AMP) was founded in 1995 to provide structure and leadership to the emerging field of molecular diagnostics. AMP's 2,300+ members include individuals from academic and community medical centers, government, and industry; including pathologist and doctoral scientist
    https://www.amp.org/AMP/assets/File/pressreleases/2015/6-4-15_RoleoftheLaborator...
  10. 220.
    Discounts for AMP members: Join now!) For AMP members Member access to JMD (requires login) 25% off page charges for corresponding authors who are full regular members 25% off open-access fees for corresponding authors who are full regular members JMD is the highest-ranked journal in its field! Impact Factor (2025): 3.9 CiteScore (2025): 6.3 Connect with
    https://www.amp.org/resources/journal-of-molecular-diagnostics/
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