Scale (% IS), used for monitoring ... gene testing for PV (95%), ET (50-70%), and PMF (30-50%) Exon 12 mutations (~5% of PV) Therapy: JAK2 inhibitors ... erythrocytosis High VAF (>75%) is associated with disease progression ... and S505N/A in ET (5%) and PMF (5-10%) p.W515K/L and S505N/A ... predominantly exon 17 Diagnosis: CNL (100%), other myeloid neoplasms Therapy: p.T618I
https://www.amp.org/AMP/assets/File/education/MIMP/MPN.pdf?pass=88