Open Public Comment

Open public comment periods allow key stakeholders to review guideline draft recommendation statements to help identify any errors or gaps prior to publication. This best practice guideline development process allows for greater transparency and complies with the National Academy of Medicine (formerly the Institute of Medicine) standards. Open public comment additionally enables AMP to engage with a diverse group of interested stakeholders around the world, provide a higher-quality product to the AMP membership, and facilitate guideline implementation and dissemination efforts.

AMP Guidelines are available for a 2- to 3-week open comment period. Individual reviewers submit their comments anonymously through a SurveyMonkey form. An alternate form may be available for organizations to submit their comments. All comments are reviewed and considered by the subject matter expert guideline development panel. Any changes made to the draft recommendations from the open comment process will be reviewed and approved by the guideline panel. Comments are advisory only and AMP is not required to make any changes based on feedback from open comment. AMP will not respond to reviewers or post responses to comments.

Available for Open Comment

AMP is pleased to announce an open comment period for the Validation of Next-Generation Sequencing Panels for Gene Fusion and Splice Variant Detection Draft Recommendations.

The AMP Gene Fusions Working Group was convened to develop an evidence-based practice guideline for the clinical use of NGS to detect somatic gene fusions and splice sites in NGS panel assays and develop best practice recommendations. The Working Group will review and consider all comments received.

The open comment period will close June 25, 2026, at 11:59 PM Eastern (US).

The Validation of Next-Generation Sequencing Panels for Gene Fusion and Splice Variant Detection Draft Recommendations were developed based upon a literature search performed for studies published from January 1, 2017 through July 12, 2023. A viewable copy of the draft recommendations is available for your review. After this open comment period, the Working Group will conduct a literature search refresh and incorporate any additional findings into the final published recommendations.

These recommendations are to be considered in their draft form and subject to change based upon the comments gathered during this open comment period and informed by evidence gathered in the literature refresh.

The draft recommendations provided here represent time limited information and are not to be distributed, used, or considered as an accurate representation of the AMP Gene Fusions Working Group work product(s) after June 25, 2026.

The AMP Gene Fusions Project is sponsored exclusively by AMP.

Thank you for contributing your time and expertise to the AMP Gene Fusions Draft Recommendations development process during this open comment period. We look forward to your feedback to further enhance the final recommendations.

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