May 2014 Self-Test: AMP Case Report Article in CAP TODAY

Molecular assays in HIV-1 Dx and therapeutic monitoring

  1. Some individuals with HIV infection by repeated serologic testing have extremely low (<50 copies/mL) or unquantifiable HIV RNA-1 viral loads. Reasons for this discrepancy may include all of the following EXCEPT:
    1. The patient may be an "elite controller," having a rare (<1%) phenotype that have the same viral control as patients taking ART.
    2. The patient has a new HIV-1 infection and a low viral load is expected at time of seroconversion.
    3. The patient has a HIV-1 primer site mutation. Testing by an alternative assay may lead to a detectable viral load.
    4. The patient may have an HIV-2 infection.
  2. A newly diagnosed HIV-1 patient is referred to the clinical laboratory for HIV-1 viral load testing as part of his therapeutic monitoring. What viral load corresponds to suppression of viremia and successful ART therapy?
    1. 50-200 copies/mL
    2. <500 copies/mL
    3. <50 copies/mL
    4. <1,000 copies/mL
  3. Nucleic acid testing for HIV-1 is useful in which of the following clinical situations?
    1. Monitoring response to ART
    2. Diagnosing a patient in the serological window period
    3. Identifying an elite controller
    4. All of the above

ANSWERS to Self-Test for May 2014 Case

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