February 2013 Self-Test: AMP Case Report Article in CAP TODAY
- Zygomycoses are important to recognize and treat aggressively in immunocompromised patients due to a highly morbid and often fatal clinical course. Which statement is false?
- Zygomycosis may cause a rapidly fatal, clinically obscure infection even in non-immunocompromised patients.
- As a class of antifungals, azoles have good efficacy against Zygomycetes.
- The stomach is the most common site of infection in gastrointestinal zygomycoses.
- Zygomycoses may infect a wide range of tissue sites, possibly leading to uncommon presentations that evade early detection.
- In tissue, zygomycosis may show variation from normal characteristic morphology (variable-width ribbon-like hyphae, irregular branching, aseptate), but are typically PAS positive and silver negative. Classic Zygomycete morphology includes:
- 45-degree branching.
- Narrow filamentous hyphae.
- Budding yeast forms.
- Fruiting bodies.
- No to weak reactivity with silver special stains.
- Molecular identification of organisms in paraffin-embedded tissues is a rapid and accurate diagnostic test, and if done in a timely manner, can guide clinical therapies. Which diagnostic modality cannot identify fungal organisms beyond the genera level?
- Fungal culture.
- Ribosomal DNA sequencing.
- Histomorphology and special stains.
- MALDI-TOF mass spectrometry.
ANSWERS to Self-Test for February 2013 Case