EDUCATION

August 2013 Self-Test: AMP Case Report Article in CAP TODAY

Importance of screening for Lynch syndrome in patients with EC

A 48-year-old woman with endometrial cancer

  1. What is the mode of inheritance for Lynch Syndrome?
    1. X-Linked
    2. Mitochondrial
    3. Autosomal Dominant
    4. Autosomal Recessive
  2. What is the expected IHC pattern associated with a genetic defect in MSH6?
    1. MSH6(+) / MSH2 (-)
    2. MSH6(+) / MSH2 (+)
    3. MSH6 (-) / MSH2 (-)
    4. MSH6 (-) / MSH2 (+)
  3. What is the most common cause of Microsatellite instability (MSI) in endometrial carcinoma?
    1. MLH1 Promoter methylation
    2. MLH1 Germline mutation
    3. MSH6 Germline mutation
    4. PMS2 Germline mutation

ANSWERS to Self-Test for August 2013 Case

Corporate Partners