April 2015 Self-Test: AMP Case Report Article in CAP TODAY

Colorectal carcinoma with germline MLH1 promoter hypermethylation

  1. Which is considered a feature of an MSI-H colon cancer?
    1. Many tumor infiltrating lymphocytes
    2. Mucinous features and signet ring cells
    3. Right side location
    4. None of the above
    5. All of the above
  2. If a patient is found to have Lynch syndrome, what are the chances that their grandchild will inherit the mutation?
    1. 50%
    2. 0%
    3. 25%
    4. 100%
    5. None of the above
  3. Which relationship between microsatellite repeats and mismatch repair proteins is correct?
    1. Mismatch repair proteins methylate microsatellite repeats
    2. Mismatch repair proteins correct microsatellite sequences which often have a high rate of error
    3. Mismatch repair mutations are due to microsatellite sequence methylation
    4. Microsatellite instability is most often due to inherited mutations in the mismatch repair proteins

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