Association for Molecular Pathology

Self-Test: AMP Case Report Article in CAP TODAY

NaCGH as a diagnostic aid in a childhood Spitzoid melanoma

September 2013


1. Which of the following ancillary techniques is (are) used in diagnosis of melanoma?
  a) Immunohistochemistry (IHC)
  b) Fluorescence in situ hybridization (FISH)
  c) Array comparative genomic hybridization (aCGH)
  d) All of the above
  e) None of the above
2. Which of the following genetic abnormalities supports a diagnosis of melanoma?
  a) CDKN2A (p16 gene) mutations
  b) Multiple chromosomal gains and losses
  c) BRAF (V600E) mutations
  d) GNAQ mutations
  e) All of the above
3) True or False: The finding of deleterious CDKN2A (p16) mutations in melanoma tumor cells is an indication of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome?