2010 Recipient of the AMP Award for Excellence in Molecular Diagnostics
Patrick O. Brown, MD, PhD is this year's recipient of AMP's Award for Excellence in Molecular Diagnostics. He is being honored for his pioneering work in studying patterns of gene expression in development and disease, as well as the development of DNA microarrays, a technical and philosophical advance that has transformed our understanding of cellular regulatory processes.
Dr. Brown received a Bachelors degree in Chemistry, a PhD in Biochemistry and MD from the University of Chicago. Upon completing a Residency in Pediatrics, he was a post-doctoral fellow with J. Michael Bishop and Harold Varmus (1985-1988) at the University of California, San Francisco and is a Professor of Biochemistry at the Stanford University School of Medicine. His early research interest was in retroviral DNA integration supplemented by novel approaches to studying genetic mapping and the application of microarrays to evaluate gene expression patterns. In addition to his studies on global post transcriptional regulation of gene expression and the patterns for gene expression in human malignancies, Dr. Brown maintains on going projects directed to understanding the cellular and molecular architecture of tissue and tumor microenvironments, the mechanisms and logic of sub-cellular localization and trafficking of mRNA, and the composition of microbial communities in individuals. Along with Micheal Eisen and Harold Varmus, Patrick founded the Public Library of Science (PLoS), a nonprofit open-access scientific publishing project aimed at creating a library of open access journals and other scientific literature under an open account license.
In 1988, Patrick Brown became an investigator of the Howard Hughes Medical Institute, elected to the United States National Academy of Sciences and is a Fellow in the American Association for the Advancement of Science. He is also the recipient of numerous awards: the Medal of Honor from the American Cancer Society, the Curt Stern Award from the American Society of Human Genetics, the NAS Award in Molecular Biology from the National Academy of Sciences, and the Biotech Helsinki Prize from the Finnish National Fund for Research and Development.